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Timeouts on incoming SMTP connections are most often related to system resources and the allocation thereof.
Check how many simultaneous incoming SMTP connections you allow. This is controlled by the MAX_PROCS and MAX_CONNECTIONS Dispatcher settings for the SMTP service; the number of simultaneous connections allowed is MAX_PROCS*MAX_CONNECTIONS. If you can afford the system resources, consider raising this number if it is too low for your usage.
Try putting the slave_debug keyword on the channels 
handling incoming SMTP over TCP/IP mail, usually tcp_local. Then look 
at the resulting tcp_local_slave.log log files and try to 
spot any particular characteristics of the messages that time out. For 
instance, if incoming messages with large numbers of recipients are 
timing out, consider using the expandlimit keyword on the 
channel.
Of course, if your system is extremely overloaded and overextended, time outs will be difficult to avoid entirely.
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